My friends, if there were a Guinness world records that were dedicated to a high-achieving rodent, Mouse UT2598, would most definitely deserve a mention, why? The average life span for a mouse is 2.3 years-so having lived 1,259, days, or about 3.45 years, before her death in 2010, little Missy had an improbably long life. In fact, this little mouse had a real shot at beating the record for the longest-lived, which as of today stands at about 4. Translating that to a human life span, she hovered around the centennial mark. However, on the outside, little Missy looked no different from her much younger brethren.
Her fur was glossy black, she was very lean, and a bit on the small side, she was no doubt scrappy and surprisingly active as she explored, always sniffed and poked around her cage that was at the University of Texas Health Science Center at San Antonio (UTHSCSA). What gave her the edge was a compound that is called rapamycin, which seems to slow the aging process and the damage that comes with it, at least to certain cells. Mouse UT2598 liver and heart functioned as if they were much younger, and her tendons had more flexibility and spring than they should have had at her age. There was also less evidence of tumors in little Missy organs than is considered normal, so she was definitely spared the effects of cancer longer. When she was placed alongside other mice that was her age, the contrast was without a doubt unmistakable.
Mouse UT2598 is only one example of the kind of research into aging that is producing remarkable new findings-and raising a lot of new questions as each day goes by. Around the world, researchers in labs are testing all sorts of agents, some of which already exist as drugs to treat some human conditions (rapamycin is given to transplant patients to prevent any organ rejection after the surgery) and some that are purely experimental. Scientists are now also toying around with ways to manipulate the genes and pluck out aging cells, all in a mouth-watering race to find a way to extend longevity to its unfamiliar outer limits.
These efforts mark a unique push to examine the basic mechanisms of aging and find ways to counteract or cure them. And they are true, anything but fringe. Longevity research is now being conducted by some of the most respected scientists, with sound reasons for staking their successful careers on the hubristic notion that it is possible to slow down the process and maybe even reverse aging.
“When I got into this field, the very notion that we could actually do anything about the aging process was only viewed as a crackpot idea”, Mr Richard Miller says, who is the director of the Glenn Center for the Biology of Aging at the University of Michigan. The argument that we can slow aging, and the diseases of aging along with it, used to be only fantasy, however, now we see it as a real scientific strategy.
No one is talking about trying to live forever, however, as these experts see it, aging is the single most powerful factor in all the diseases that are most likely to cut our lives short: cancer, immune disorders, heart problems and degenerative brain conditions like that terrible Alzheimer’s. “Everybody knows well that the main risk factors for heart disease are in fact high cholesterol, high blood pressure and obesity”, Felipe Sierra says, who is the director of the division of aging biology at the National Institute on Aging (NIA).
But ever stronger than those factors is being 70 years old. And that is why staving off aging-or at the very least slowing it-has become such an important focus of research. We’re going towards aging it-self, David Sinclair says, who is a geneticist at the Havard Medical School. We might take somebody who is showing some signs of aging and be equipped and able to do something about it, to treat aging as a disease. And that is something I never expected to see in my lifetime.
It turns out that rapamycin interrupts the function of a gene called mTOR, which is found in both man and mouse, it acts as a traffic signal for directing how the cell takes in and utilizes energy. If there is plenty to eat, the gene becomes busy green-lighting cells to absorb the nutrients and grow and grow. When food becomes scarce, the gene than become quiet, halting the cell-growing machinery until it is time for feeding again. While mTOR may explain, in some part, this phenomenon of calorie restriction and its ability to prolong life-in the 1930s, the studies in mice showed by cutting back on their daily diet could add all-most a year to their lives there is also some evidence that it taps into other energy-related pathways to a longer life as well.
A pilot study published in 2018 examined the safety and tolerability of a short-term rapamycin treatment in generally healthy older adults, which was not previously demonstrated. This study showed that short-term rapamycin treatment can be used safely in older men and women who are considered otherwise being healthy. However, a larger-size trial and longer treatment duration are warranted.
Are rapamycin-fed mice living longer only because their cells are actually functioning like the younger ones or because they’re simply delaying aging conditions like heart disease and cancer? And while we are learning more every day about the real role telomeres play in the process of aging, is the true answer as simple as finding the ways to safely lengthen them through drugs? These are not very easy questions to answer, however, the aging experts welcome them. It is because what’s happening in the labs is not all about extending a life indefinitely but rather extending a healthy life for a little longer.
It may all sound a little like science fiction, however, we are really walking through the door of a new era of prolonging life for the human species. May you be always in good health, humbly yours Paul Earl.
20 thoughts on “AGING AGING AGING”
Hello Paul, this is some remarkable information that you have provided, I had to come back to your website twice to read this. I didn’t even have any idea that we had research involving this, this is amazing as you said it sounds like science fiction, however I know it to be the real thing, and hopefully they will have it to the point that we can live longer, thank you so much for providing this information.
Good evening Robert, thank for visiting W.L.F.A.B.W. Yes indeed my friend, we are now witnessing a major breakthrough for mankind. Considering the intensity of the scientist, I personally believe we’re not far away from the day that we can take a pill or a shot to live longer. May you be always in good health. If it is anything that we can do for you please reach out to us. Humbly yours Paul Earl.
I always believe that just soon enough, w humans will invent the right things to combat all our problems and this is like another bigger step in the right direction. Thank you so much for sharing this findings. Good to see that there are researches being carried on processes to slow our rate of aging and just like it worked for the Mouse UT2598, it will soon be perfected for humans too.
Good evening Rodarrick, thank you for visiting weightlifting for beautiful world once again, is always very good to see you. Yes indeed my friend I to believe in my heart that somewhere on this planet the research was beginning or very intensity moving forward. Even with the information that my team and I have provided, I am sure there is much more they has not been provided for the eyes and ears of society as of yet, I also believe however, I have no facts that the rhoten’s was not the only one that these experiments have been tried on, if you catch my drift. Yes indeed we are now living in a Brave New World and there is no doubt in my mind there will be a way to increase life that will be made available, however what is going to be the price tag on it, and will it be made available for the general Public, that is the real question. As always my friend if it’s anything at all that we can do for you, do not hesitate to reach out to us. May you be always in good health humbly yours Paul Earl.
I had to read this a few times to get your message, but once I did, it was hard to discard it. As a personal trainer, I can understand how little Missy lasted so long. She seems to have mastered something we all humans need to get behind, which is developing strong long-lasting bodies. A great way to explain, if a little mouse can extend their lifespan, then there is no reason why humasn can’t do the same.
Good evening Eric, thank you for visiting weightlifting for a beautiful world. I feel the same way as you do, if little missy was able to utilize this technique with this chemical, it won’t be long, if it hasn’t been done already, before humans are using this technique with this chemical. In fact I will go one step farther I believe the experiment has already been done, however, I have no facts on this. You can bet your bottom dollar, it will be available more than likely In Our Lifetime, however, the question is, who will it be available to. Once again thank you for visiting us, and if it’s anything we can do for you, do not hesitate to reach out to us. May you be always in good health, humbly yours Paul Earl.
Wow, that is some heavy stuff in the research there. Manipulating genes to give people a longer life. Scary!
It really does sound like something from a science fiction novel but it seems that there is some real evidence to support this.
What do you think about the moral implications of such a thing actually being available to the general public?
Good evening Tony, my brother this is my feelings, it has been going on for a lot longer then they are telling us, in fact I believe they have come much farther than they are telling us. In fact I believe it has already been done with a human species, however, I have no facts to support this. As far as your question goes, it is the belief of my team and myself, it will be available within our lifetime, however, the question is, who will it be available to, if you catch my drift Tony. As always if it’s anything that we can do for you please reach out to us. And we thank you for visiting weightlifting for a beautiful world. May you be always in good health, humbly yours Paul Earl.
Very informational article. I love to lift and love this article even more. I was expecially interested in the part where you explain how science might be able to identify and remove the “aging gene” for added longevity. Im very interested to see how that plays out. Definatly sharing this post now.
Good evening Justin, thank you for visiting weightlifting for a beautiful world. I just mentioned to one of my readers Tony, that I believe they have come a lot harder than they are telling us, in fact I believe they have had some success with a human species, however, I have no facts to support this. And yes I definitely believe it will be made available in our lifetime. We thank you once again for visiting us, and if it’s anything ever that we can do for you please contact us. May you be always in good health, humbly yours Paul Earl.
Being 73, this topic has currency with me. But aging is a topic for all ages. It hits at the core of what it means to be human. As you address your topic, you bring us to see the possibilities of confronting aging from a purely scientific perspective. This opens the door to gaining a perspective of aging as an evolutionary pathway. Aging is a great topic for a health blog. I found the article in general to be informative for the topic. I was satisfied with your approach. I also appreciated that your topic and title were not misleading. I find that too often topic and article is just a shell game to get the reader to a sales page. Keep up the good work.
Good evening bjgteach, thank you for visiting weightlifting for a beautiful world. My team and I are on a mission, to help as many people that we possibly can to live a long quality life. We put in hundreds of hours of research, Time After Time and Again, to gather the facts medically and scientifically, so that we can give the truth to our readers. This article has shown the possibilities in this new research that is developing, it is our belief here at weightlifting for a beautiful world, that in our lifetime, this will be made available for the human species. If he’s ever anything at all that we can do for you please reach out to us. May you be always in good health humbly yours Paul Earl.
Very nice article, this is some pretty heady stuff man. I’m very interested in stopping or at least slowing down the aging process myself. I’m only in my mid thirties, but I have become acutely aware of time flying by me and it causes me to even have anxiety sometimes. I’m also really interested in the other side of things with artificial intelligence being able to maybe solve some of these problems we haven’t been able to. It’s a very exciting time to be alive. How much do you think technology, maybe even cybernetic implants, is going to play a role in anti-aging in your opinion?
Good evening riverdogg, thank you for stopping by weightlifting for a beautiful world, I am always, happy to see new readers. As I have mentioned to other readers I believe that this new research, will be completed within our lifetime and a product will be made available for Humanity. Concerning artificial intelligence, my team and I have done some privilege research, and in China, the scientists there, have already come up with artificial intelligence being in a man-made body, and it is working, however it is in the beginning stages, I am sure this is going to be huge, and of course you going to have many that are not going to be responding in a positive way because of what they feel it made represent.. We thank you for visiting us here, and if it’s ever anything at all that we can do for you, by all means reach out to us. May you be always in good health, humbly yours, Paul Earl.
Aging is the single most difficult issue that we all face in this current world that we are in and it requires the general consensus to tackle it and just hat, this post has addressed it in full. though it still look a little bit more filled with languages of science that is not easy to decipher but I’m sure that with time, everything would come out plain ad we will all know how to prolong our lives more better.
Good evening Rodarrick, thank you for visiting weightlifting for a beautiful world. Before I go on, I want a mention to you about the word approach, my team and I, put in hundreds of hours in research before we write these articles, the terminology of science is the only way you can give the evidence that must be presented in order to formulate the story. It is just no other way, you have to use the facts, without the facts you have nothing but hearsay. Yes indeed this technology is going to change the world, it is our belief we will see this come about within our lifetime. Once again thank you for visiting us, if it’s anything that we could ever do for you please reach out to us may you be always in good health humbly yours Paul Earl.
Very interesting and informative article on aging. I am familiar with rapamycin and its affects on post transplant cancer patients but I was not aware of its anti-aging properties. I think that if Rapamycin increases lifespan by slowing aging or inhibits metabolic diseases that we need more research in this area for sure.
Thank you for a wonderful insightful article
Good evening Tammy, so very nice to see you again, we all ways love when you stop by. It is my belief, in fact it is my team also belief, that, they are a lot farder with this technology than they are letting us believe, however I have no facts to back this up. One thing I definitely believe, and that is we will see this happen in our lifetime. As you have said if it could be done for roten’s he’s no doubt it will be done for the human species. as always we thank you for visiting weightlifting for Beautiful World, and if it’s anything that we can possibly do for you please reach out to us. May you be always in good health, humbly request you to yours Paul Earl.
This is one a fabulous article , I never seen . The powerful of this story is coming from a good storyteller .I love , when some people are breakdown everything about be healthy , and have a good shape . There are so many good vitamins that’s make people healthy . To staying for long time , you need to be exercising , eating fruits , and healthier food .
Good evening Saul, thank you for visiting Weightlifting For A Beautiful World. If you read any of my article on this website, you will find out this website is about helping man and woman to be healthy and to life a quality life. I an continuously preaching exercise, the right foods, the correct vitamins. My team and I literally put in hundreds of hours or more a week in research, gathering information that we believe will help humanity to live that quality life. We here at W.L.F.A.B.W., have known for months about this new research that scientists all over the world are engaged in, that most of society is not aware of. So today we give that real and truthful information to our sisters and brothers of the world. If it’s ever anything that we can do for you, by all means reach out to us. May you be always in good health, humbly your Paul Earl.